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Noteworthy, the isolated MVs may have both direct (i.e., the transmission of growth factors and transcripts) and indirect (i.e., stem cell recruitment) effects on skin regeneration

Flushing, headache, nausea, and local irritation are the leading complaints and usually resolve when infusion speed is reduced

Peer review Peer review information Nature Communications thanks Toni Giorgino and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

This article covers exactly how those mechanisms interact, what the research shows about combination protocols, and what preparation mistakes negate the benefit entirely

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